Human PDIA6 activation kit by CRISPRa

CAT#: GA106874

PDIA6 CRISPRa kit - CRISPR gene activation of human protein disulfide isomerase family A member 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDIA6
• Locus ID: 10130
• Kit Components:

  GA106874G1, PDIA6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106874G2, PDIA6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106874G3, PDIA6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282704, NM_001282705, NM_001282706, NM_001282707, NM_005742
• Synonyms: ERP5; P5; TXNDC7
• Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]