Human RASA4 activation kit by CRISPRa

CAT#: GA106896

RASA4 CRISPRa kit - CRISPR gene activation of human RAS p21 protein activator 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RASA4
• Locus ID: 10156
• Kit Components:

  GA106896G1, RASA4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106896G2, RASA4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106896G3, RASA4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001079877, NM_006989
• Synonyms: CAPRI; GAPL
• Summary: This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]