Human RBM5 activation kit by CRISPRa

CAT#: GA106917

RBM5 CRISPRa kit - CRISPR gene activation of human RNA binding motif protein 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RBM5
• Locus ID: 10181
• Kit Components:

  GA106917G1, RBM5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106917G2, RBM5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106917G3, RBM5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005778, NR_036627
• Synonyms: G15; H37; LUCA15; RMB5
• Summary: This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]