Human ACK1 (TNK2) activation kit by CRISPRa

CAT#: GA106920

TNK2 CRISPRa kit - CRISPR gene activation of human tyrosine kinase non receptor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNK2
• Locus ID: 10188
• Kit Components:

  GA106920G1, TNK2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106920G2, TNK2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106920G3, TNK2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001010938, NM_001308046, NM_005781
• Synonyms: ACK; ACK-1; ACK1; p21cdc42Hs
• Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]