Human p53 BP3 (TOPORS) activation kit by CRISPRa

CAT#: GA106940

TOPORS CRISPRa kit - CRISPR gene activation of human TOP1 binding arginine/serine rich protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TOPORS
• Locus ID: 10210
• Kit Components:

  GA106940G1, TOPORS gRNA vector 1 in pCas-Guide-CRISPRa

  GA106940G2, TOPORS gRNA vector 2 in pCas-Guide-CRISPRa

  GA106940G3, TOPORS gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001195622, NM_005802
• Synonyms: LUN; P53BP3; RP31; TP53BPL
• Summary: This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]