Human BMP11 (GDF11) activation kit by CRISPRa

CAT#: GA106950

GDF11 CRISPRa kit - CRISPR gene activation of human growth differentiation factor 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GDF11
• Locus ID: 10220
• Kit Components:

  GA106950G1, GDF11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106950G2, GDF11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106950G3, GDF11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005811
• Synonyms: BMP-11; BMP11
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role in the development of the nervous and other organ systems, and may regulate aging. [provided by RefSeq, Aug 2016]