Human KCNMB2 activation kit by CRISPRa

CAT#: GA106970

KCNMB2 CRISPRa kit - CRISPR gene activation of human potassium calcium-activated channel subfamily M regulatory beta subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNMB2
• Locus ID: 10242
• Kit Components:

  GA106970G1, KCNMB2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106970G2, KCNMB2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106970G3, KCNMB2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278911, NM_005832, NM_181361
• Summary: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]