Human Gephyrin (GPHN) activation kit by CRISPRa

CAT#: GA106971

GPHN CRISPRa kit - CRISPR gene activation of human gephyrin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: GPHN
• Locus ID: 10243
• Kit Components:

  GA106971G1, GPHN gRNA vector 1 in pCas-Guide-CRISPRa

  GA106971G2, GPHN gRNA vector 2 in pCas-Guide-CRISPRa

  GA106971G3, GPHN gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024218, NM_020806
• Synonyms: GEPH; GPH; GPHRYN; HKPX1; MOCODC
• Summary: This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known. [provided by RefSeq, Jul 2008]