Human SF3B4 activation kit by CRISPRa

CAT#: GA106987

SF3B4 CRISPRa kit - CRISPR gene activation of human splicing factor 3b subunit 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SF3B4
• Locus ID: 10262
• Kit Components:

  GA106987G1, SF3B4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106987G2, SF3B4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106987G3, SF3B4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005850
• Synonyms: AFD1; Hsh49; SAP49; SF3b49
• Summary: This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008]