Human IRX5 activation kit by CRISPRa

CAT#: GA106989

IRX5 CRISPRa kit - CRISPR gene activation of human iroquois homeobox 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IRX5
• Locus ID: 10265
• Kit Components:

  GA106989G1, IRX5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106989G2, IRX5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106989G3, IRX5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001252197, NM_005853
• Synonyms: HMMS; IRX-2a; IRXB2
• Summary: This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]