Human RTN3 activation kit by CRISPRa

CAT#: GA107027

RTN3 CRISPRa kit - CRISPR gene activation of human reticulon 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RTN3
• Locus ID: 10313
• Kit Components:

  GA107027G1, RTN3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107027G2, RTN3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107027G3, RTN3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001265589, NM_001265590, NM_001265591, NM_006054, NM_201428, NM_201429, NM_201430, NR_049750, NR_049751
• Synonyms: ASYIP; HAP; NSPL2; NSPLII; RTN3-A1
• Summary: This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]