Human SIRPB1 activation kit by CRISPRa

CAT#: GA107038

SIRPB1 CRISPRa kit - CRISPR gene activation of human signal regulatory protein beta 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SIRPB1
• Locus ID: 10326
• Kit Components:

  GA107038G1, SIRPB1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107038G2, SIRPB1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107038G3, SIRPB1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001083910, NM_001135844, NM_001329157, NM_001330639, NM_006065
• Synonyms: CD172b; SIRP-BETA-1
• Summary: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]