Human HMG20A activation kit by CRISPRa

CAT#: GA107061

HMG20A CRISPRa kit - CRISPR gene activation of human high mobility group 20A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HMG20A
• Locus ID: 10363
• Kit Components:

  GA107061G1, HMG20A gRNA vector 1 in pCas-Guide-CRISPRa

  GA107061G2, HMG20A gRNA vector 2 in pCas-Guide-CRISPRa

  GA107061G3, HMG20A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001304504, NM_001304505, NM_018200
• Synonyms: HMGX1; HMGXB1
• Summary: Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4. [UniProtKB/Swiss-Prot Function]