Human BPNT1 activation kit by CRISPRa

CAT#: GA107070

BPNT1 CRISPRa kit - CRISPR gene activation of human 3'(2'), 5'-bisphosphate nucleotidase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BPNT1
• Locus ID: 10380
• Kit Components:

  GA107070G1, BPNT1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107070G2, BPNT1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107070G3, BPNT1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286149, NM_001286150, NM_001286151, NM_006085
• Synonyms: HEL20; PIP
• Summary: BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]