Human Apc10 (ANAPC10) activation kit by CRISPRa

CAT#: GA107081

ANAPC10 CRISPRa kit - CRISPR gene activation of human anaphase promoting complex subunit 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ANAPC10
• Locus ID: 10393
• Kit Components:

  GA107081G1, ANAPC10 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107081G2, ANAPC10 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107081G3, ANAPC10 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256706, NM_001256707, NM_001256708, NM_001256709, NM_001256710, NM_001256711, NM_001256712, NM_001318367, NM_014885, NR_046345
• Synonyms: APC10; DOC1
• Summary: ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]). [supplied by OMIM, Feb 2011]