Human PIAS3 activation kit by CRISPRa

CAT#: GA107089

PIAS3 CRISPRa kit - CRISPR gene activation of human protein inhibitor of activated STAT 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PIAS3
• Locus ID: 10401
• Kit Components:

  GA107089G1, PIAS3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107089G2, PIAS3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107089G3, PIAS3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006099
• Synonyms: ZMIZ5
• Summary: This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]