Human SPAG11B activation kit by CRISPRa

CAT#: GA107094

SPAG11B CRISPRa kit - CRISPR gene activation of human sperm associated antigen 11B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPAG11B
• Locus ID: 10407
• Kit Components:

  GA107094G1, SPAG11B gRNA vector 1 in pCas-Guide-CRISPRa

  GA107094G2, SPAG11B gRNA vector 2 in pCas-Guide-CRISPRa

  GA107094G3, SPAG11B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_016512, NM_058200, NM_058201, NM_058202, NM_058203, NM_058206, NM_058207
• Synonyms: EDDM2B; EP2; EP2C; EP2D; HE2; HE2C; SPAG11
• Summary: This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]