Human SEC24B activation kit by CRISPRa

CAT#: GA107110

SEC24B CRISPRa kit - CRISPR gene activation of human SEC24 homolog B, COPII coat complex component

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SEC24B
• Locus ID: 10427
• Kit Components:

  GA107110G1, SEC24B gRNA vector 1 in pCas-Guide-CRISPRa

  GA107110G2, SEC24B gRNA vector 2 in pCas-Guide-CRISPRa

  GA107110G3, SEC24B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001042734, NM_001300813, NM_001318085, NM_001318086, NM_006323
• Synonyms: SEC24
• Summary: The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]