Human UNC13B activation kit by CRISPRa

CAT#: GA107171

UNC13B CRISPRa kit - CRISPR gene activation of human unc-13 homolog B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UNC13B
• Locus ID: 10497
• Kit Components:

  GA107171G1, UNC13B gRNA vector 1 in pCas-Guide-CRISPRa

  GA107171G2, UNC13B gRNA vector 2 in pCas-Guide-CRISPRa

  GA107171G3, UNC13B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006377, NM_001330653
• Synonyms: MUNC13; UNC13; Unc13h2
• Summary: This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]