Human Fibulin 5 (FBLN5) activation kit by CRISPRa

CAT#: GA107182

FBLN5 CRISPRa kit - CRISPR gene activation of human fibulin 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FBLN5
• Locus ID: 10516
• Kit Components:

  GA107182G1, FBLN5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107182G2, FBLN5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107182G3, FBLN5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006329
• Synonyms: ADCL2; ARCL1A; ARMD3; DANCE; EVEC; FIBL-5; HNARMD; UP50
• Summary: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]