Human Dynamitin (DCTN2) activation kit by CRISPRa

CAT#: GA107204

DCTN2 CRISPRa kit - CRISPR gene activation of human dynactin subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DCTN2
• Locus ID: 10540
• Kit Components:

  GA107204G1, DCTN2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107204G2, DCTN2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107204G3, DCTN2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001261412, NM_001261413, NM_006400, NM_001348065, NM_001348066, NM_001348067, NM_001348068, NR_145419
• Synonyms: DCTN50; DYNAMITIN; HEL-S-77; RBP50
• Summary: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]