Human AGR2 activation kit by CRISPRa

CAT#: GA107211

AGR2 CRISPRa kit - CRISPR gene activation of human anterior gradient 2, protein disulphide isomerase family member

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: AGR2
• Locus ID: 10551
• Kit Components:

  GA107211G1, AGR2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107211G2, AGR2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107211G3, AGR2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006408
• Synonyms: AG2; GOB-4; HAG-2; HEL-S-116; PDIA17; XAG-2
• Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]