Human SPTLC1 activation kit by CRISPRa

CAT#: GA107218

SPTLC1 CRISPRa kit - CRISPR gene activation of human serine palmitoyltransferase long chain base subunit 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPTLC1
• Locus ID: 10558
• Kit Components:

  GA107218G1, SPTLC1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107218G2, SPTLC1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107218G3, SPTLC1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001281303, NM_006415, NM_178324, NM_001368273, NM_001368272
• Synonyms: HSAN1; HSN1; LBC1; LCB1; SPT1; SPTI
• Summary: This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. [provided by RefSeq, Jul 2013]