Human SH2B2 activation kit by CRISPRa

CAT#: GA107257

SH2B2 CRISPRa kit - CRISPR gene activation of human SH2B adaptor protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SH2B2
• Locus ID: 10603
• Kit Components:

  GA107257G1, SH2B2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107257G2, SH2B2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107257G3, SH2B2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_020979, NM_001359228, NM_001359229, NM_001359230, NM_001359231
• Synonyms: APS
• Summary: The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]