Human PMVK activation kit by CRISPRa

CAT#: GA107302

PMVK CRISPRa kit - CRISPR gene activation of human phosphomevalonate kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PMVK
• Locus ID: 10654
• Kit Components:

  GA107302G1, PMVK gRNA vector 1 in pCas-Guide-CRISPRa

  GA107302G2, PMVK gRNA vector 2 in pCas-Guide-CRISPRa

  GA107302G3, PMVK gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006556, NM_001323011, NM_001323012, NM_001348696
• Synonyms: HUMPMKI; PMK; PMKA; PMKASE; POROK1
• Summary: This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]