Human ATP dependent metalloprotease YME1L1 (YME1L1) activation kit by CRISPRa

CAT#: GA107351

YME1L1 CRISPRa kit - CRISPR gene activation of human YME1 like 1 ATPase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: YME1L1
• Locus ID: 10730
• Kit Components:

  GA107351G1, YME1L1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107351G2, YME1L1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107351G3, YME1L1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001253866, NM_014263, NM_139312, NM_139313
• Synonyms: FTSH; MEG4; PAMP; YME1L
• Summary: The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]