Human MASP2 activation kit by CRISPRa

CAT#: GA107365

MASP2 CRISPRa kit - CRISPR gene activation of human mannan binding lectin serine peptidase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MASP2
• Locus ID: 10747
• Kit Components:

  GA107365G1, MASP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107365G2, MASP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107365G3, MASP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006610, NM_139208
• Synonyms: MAP19; MASP-2; MASP1P1; sMAP
• Summary: This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]