Human FUSIP1 (SRSF10) activation kit by CRISPRa

CAT#: GA107381

SRSF10 CRISPRa kit - CRISPR gene activation of human serine and arginine rich splicing factor 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SRSF10
• Locus ID: 10772
• Kit Components:

  GA107381G1, SRSF10 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107381G2, SRSF10 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107381G3, SRSF10 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001191005, NM_001191006, NM_001191007, NM_001191009, NM_001300936, NM_001300937, NM_006625, NM_054016, NR_034035
• Synonyms: FUSIP1; FUSIP2; NSSR; PPP1R149; SFRS13; SFRS13A; SRp38; SRrp40; TASR; TASR1; TASR2
• Summary: This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]