Human CysLT1 (CYSLTR1) activation kit by CRISPRa

CAT#: GA107401

CYSLTR1 CRISPRa kit - CRISPR gene activation of human cysteinyl leukotriene receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYSLTR1
• Locus ID: 10800
• Kit Components:

  GA107401G1, CYSLTR1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107401G2, CYSLTR1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107401G3, CYSLTR1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282186, NM_001282187, NM_001282188, NM_006639
• Synonyms: CYSLT1; CYSLT1R; CYSLTR; HMTMF81
• Summary: This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]