Human CCR9 activation kit by CRISPRa

CAT#: GA107404

CCR9 CRISPRa kit - CRISPR gene activation of human C-C motif chemokine receptor 9

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CCR9
• Locus ID: 10803
• Kit Components:

  GA107404G1, CCR9 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107404G2, CCR9 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107404G3, CCR9 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256369, NM_006641, NM_031200, NR_036525
• Synonyms: CC-CKR-9; CDw199; GPR-9-6; GPR28
• Summary: The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]