Human PDE10A activation kit by CRISPRa

CAT#: GA107427

PDE10A CRISPRa kit - CRISPR gene activation of human phosphodiesterase 10A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PDE10A
• Locus ID: 10846
• Kit Components:

  GA107427G1, PDE10A gRNA vector 1 in pCas-Guide-CRISPRa

  GA107427G2, PDE10A gRNA vector 2 in pCas-Guide-CRISPRa

  GA107427G3, PDE10A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130690, NM_006661, NR_045597
• Synonyms: HSPDE10A
• Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]