Human Heparanase 1 (HPSE) activation kit by CRISPRa

CAT#: GA107432

HPSE CRISPRa kit - CRISPR gene activation of human heparanase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HPSE
• Locus ID: 10855
• Kit Components:

  GA107432G1, HPSE gRNA vector 1 in pCas-Guide-CRISPRa

  GA107432G2, HPSE gRNA vector 2 in pCas-Guide-CRISPRa

  GA107432G3, HPSE gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001098540, NM_001166498, NM_001199830, NM_006665
• Synonyms: HPA; HPA1; HPR1; HPSE1; HSE1
• Summary: Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]