Human CYP46 (CYP46A1) activation kit by CRISPRa

CAT#: GA107435

CYP46A1 CRISPRa kit - CRISPR gene activation of human cytochrome P450 family 46 subfamily A member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYP46A1
• Locus ID: 10858
• Kit Components:

  GA107435G1, CYP46A1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107435G2, CYP46A1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107435G3, CYP46A1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006668
• Synonyms: CP46; CYP46
• Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]