Human HCST activation kit by CRISPRa

CAT#: GA107444

HCST CRISPRa kit - CRISPR gene activation of human hematopoietic cell signal transducer

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HCST
• Locus ID: 10870
• Kit Components:

  GA107444G1, HCST gRNA vector 1 in pCas-Guide-CRISPRa

  GA107444G2, HCST gRNA vector 2 in pCas-Guide-CRISPRa

  GA107444G3, HCST gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001007469, NM_014266
• Synonyms: DAP10; KAP10; PIK3AP
• Summary: This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]