Human ME3 activation kit by CRISPRa

CAT#: GA107446

ME3 CRISPRa kit - CRISPR gene activation of human malic enzyme 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ME3
• Locus ID: 10873
• Kit Components:

  GA107446G1, ME3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107446G2, ME3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107446G3, ME3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001014811, NM_001161586, NM_006680, NM_001351934, NR_147828, NR_147829, NR_147830, NR_147831
• Synonyms: NADP-ME
• Summary: Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]