Human GPR73A (PROKR1) activation kit by CRISPRa

CAT#: GA107459

PROKR1 CRISPRa kit - CRISPR gene activation of human prokineticin receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PROKR1
• Locus ID: 10887
• Kit Components:

  GA107459G1, PROKR1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107459G2, PROKR1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107459G3, PROKR1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_138964
• Synonyms: GPR73; GPR73a; PKR1; ZAQ
• Summary: This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]