Human TXNL4A activation kit by CRISPRa

CAT#: GA107477

TXNL4A CRISPRa kit - CRISPR gene activation of human thioredoxin like 4A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TXNL4A
• Locus ID: 10907
• Kit Components:

  GA107477G1, TXNL4A gRNA vector 1 in pCas-Guide-CRISPRa

  GA107477G2, TXNL4A gRNA vector 2 in pCas-Guide-CRISPRa

  GA107477G3, TXNL4A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001303471, NM_001305557, NM_001305563, NM_001305564, NM_006701, NR_131175, NR_131176, NR_131177
• Synonyms: BMKS; DIB1; DIM1; SNRNP15; TXNL4; U5-15kD
• Summary: The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]