Human NTE (PNPLA6) activation kit by CRISPRa

CAT#: GA107478

PNPLA6 CRISPRa kit - CRISPR gene activation of human patatin like phospholipase domain containing 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PNPLA6
• Locus ID: 10908
• Kit Components:

  GA107478G1, PNPLA6 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107478G2, PNPLA6 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107478G3, PNPLA6 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166111, NM_001166112, NM_001166113, NM_001166114, NM_006702
• Synonyms: BNHS; iPLA2delta; LNMS; NTE; NTEMND; OMCS; SPG39; sws
• Summary: This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]