Human MAGED2 activation kit by CRISPRa

CAT#: GA107485

MAGED2 CRISPRa kit - CRISPR gene activation of human MAGE family member D2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAGED2
• Locus ID: 10916
• Kit Components:

  GA107485G1, MAGED2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107485G2, MAGED2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107485G3, MAGED2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006787, NM_014599, NM_177433, NM_201222
• Synonyms: 11B6; BCG-1; BCG1; HCA10; MAGE-D2
• Summary: This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked intellectual disability (XLID). Mutations in this gene cause a form of transient antenatal Bartter's syndrome. This gene may also be involved in several types of cancer, including breast cancer and melanoma. The protein encoded by this gene is progressively recruited from the cytoplasm to the nucleoplasm during the interphase and after nucleolar stress and is thus thought to play a role in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]