Human SEC61B activation kit by CRISPRa

CAT#: GA107515

SEC61B CRISPRa kit - CRISPR gene activation of human SEC61 translocon beta subunit

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SEC61B
• Locus ID: 10952
• Kit Components:

  GA107515G1, SEC61B gRNA vector 1 in pCas-Guide-CRISPRa

  GA107515G2, SEC61B gRNA vector 2 in pCas-Guide-CRISPRa

  GA107515G3, SEC61B gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006808
• Synonyms: OTTHUMP00000021784; protein translocation complex beta; protein transport protein SEC61 beta subunit; Sec61 beta subunit; Sec61 complex, beta subunit
• Summary: The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]