Human TMP21 (TMED10) activation kit by CRISPRa

CAT#: GA107532

TMED10 CRISPRa kit - CRISPR gene activation of human transmembrane p24 trafficking protein 10

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TMED10
• Locus ID: 10972
• Kit Components:

  GA107532G1, TMED10 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107532G2, TMED10 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107532G3, TMED10 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006827
• Synonyms: p23; P24(DELTA); p24d1; S31I125; S31III125; Tmp-21-I; TMP21
• Summary: This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]