Human Methionine Aminopeptidase 2 (METAP2) activation kit by CRISPRa

CAT#: GA107544

METAP2 CRISPRa kit - CRISPR gene activation of human methionyl aminopeptidase 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: METAP2
• Locus ID: 10988
• Kit Components:

  GA107544G1, METAP2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107544G2, METAP2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107544G3, METAP2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317182, NM_001317183, NM_001330246, NM_006838, NR_133673
• Synonyms: MAP2; MNPEP; p67eIF2
• Summary: The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]