Human IL24 activation kit by CRISPRa

CAT#: GA107559

IL24 CRISPRa kit - CRISPR gene activation of human interleukin 24

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL24
• Locus ID: 11009
• Kit Components:

  GA107559G1, IL24 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107559G2, IL24 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107559G3, IL24 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001185156, NM_001185157, NM_001185158, NM_006850, NM_181339
• Synonyms: C49A; FISP; IL10B; MDA7; MOB5; ST16
• Summary: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]