Human ADRM1 activation kit by CRISPRa

CAT#: GA107591

ADRM1 CRISPRa kit - CRISPR gene activation of human adhesion regulating molecule 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ADRM1
• Locus ID: 11047
• Kit Components:

  GA107591G1, ADRM1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107591G2, ADRM1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107591G3, ADRM1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001281437, NM_001281438, NM_007002, NM_175573
• Synonyms: ARM-1; ARM1; GP110
• Summary: This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]