Human ABHD2 activation kit by CRISPRa

CAT#: GA107597

ABHD2 CRISPRa kit - CRISPR gene activation of human abhydrolase domain containing 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ABHD2
• Locus ID: 11057
• Kit Components:

  GA107597G1, ABHD2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107597G2, ABHD2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107597G3, ABHD2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007011, NM_152924
• Synonyms: HS1-2; LABH2; PHPS1-2
• Summary: This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a wide range of enzymes. The encoded protein is an acylglycerol lipase that catalyzes the hydrolysis of endocannabinoid arachidonoylglycerol from the cell membrane. This leads to activation of the sperm calcium channel CatSper, which results in sperm activation. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jan 2017]