Human TOPBP1 activation kit by CRISPRa

CAT#: GA107611

TOPBP1 CRISPRa kit - CRISPR gene activation of human DNA topoisomerase II binding protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TOPBP1
• Locus ID: 11073
• Kit Components:

  GA107611G1, TOPBP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107611G2, TOPBP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107611G3, TOPBP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007027, NM_001363889
• Synonyms: TOP2BP1
• Summary: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]