Human DNAJB4 activation kit by CRISPRa

CAT#: GA107618

DNAJB4 CRISPRa kit - CRISPR gene activation of human DnaJ heat shock protein family (Hsp40) member B4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DNAJB4
• Locus ID: 11080
• Kit Components:

  GA107618G1, DNAJB4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107618G2, DNAJB4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107618G3, DNAJB4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001317099, NM_001317100, NM_001317101, NM_001317102, NM_001317103, NM_007034
• Synonyms: DjB4; DNAJW; HLJ1
• Summary: The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]