Human FGFR1 Oncogene Partner (FGFR1OP) activation kit by CRISPRa

CAT#: GA107643

FGFR1OP CRISPRa kit - CRISPR gene activation of human FGFR1 oncogene partner

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FGFR1OP
• Locus ID: 11116
• Kit Components:

  GA107643G1, FGFR1OP gRNA vector 1 in pCas-Guide-CRISPRa

  GA107643G2, FGFR1OP gRNA vector 2 in pCas-Guide-CRISPRa

  GA107643G3, FGFR1OP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278690, NM_007045, NM_194429
• Synonyms: FOP
• Summary: This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]