Human ZWINT activation kit by CRISPRa

CAT#: GA107655

ZWINT CRISPRa kit - CRISPR gene activation of human ZW10 interacting kinetochore protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ZWINT
• Locus ID: 11130
• Kit Components:

  GA107655G1, ZWINT gRNA vector 1 in pCas-Guide-CRISPRa

  GA107655G2, ZWINT gRNA vector 2 in pCas-Guide-CRISPRa

  GA107655G3, ZWINT gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001005413, NM_001005414, NM_007057, NM_032997
• Synonyms: HZwint-1; KNTC2AP; SIP30; ZWINT1
• Summary: This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]