Human IL1RAPL1 activation kit by CRISPRa

CAT#: GA107664

IL1RAPL1 CRISPRa kit - CRISPR gene activation of human interleukin 1 receptor accessory protein like 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL1RAPL1
• Locus ID: 11141
• Kit Components:

  GA107664G1, IL1RAPL1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107664G2, IL1RAPL1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107664G3, IL1RAPL1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_014271
• Synonyms: IL1R8; IL1RAPL; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2
• Summary: The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization. [provided by RefSeq, Jul 2017]